Tetanus Severity Score for Prediction of Mortality in Manifest Tetanus
Comparison of Three Scoring Systems for Prediction of Mortality in Patients Admitted to the Intensive Care Unit With Manifest Tetanus
Ain Shams University
115 participants
Jun 15, 2025
OBSERVATIONAL
Conditions
Summary
Three scoring systems will be applied to patients suffering from manifest tetanus and will be related to mortality.
Eligibility
Inclusion Criteria5
- Adults (age 18 years old or more).
- Any sex (male or female), regardless of gender identity.
- Diagnosis of manifest tetanus according to the WHO criteria (https://www.who.int/news-room/fact-sheets/detail/tetanus), that is the presence of one or both of the following criteria with or without the history of specific wound or injury:
- Sustained spasm of the facial muscles in which person appears grinning.
- Painful muscular contractions
Exclusion Criteria4
- Age < 18 years.
- Absent criteria of manifest tetanus, as per the WHO criteria (https://www.who.int/news-room/fact-sheets/detail/tetanus).
- Incomplete medical record with missing data required to calculate the Tetanus Severity Score, Philips Score, or Dakar score.
- Incomplete medical record with missing data regarding the primary outcome measure (survival to hospital discharge or in-hospital mortality).
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Interventions
The Tetanus Severity Score (TSS) is calculated for each patient by the investigator using the required data as documented in the medical records at admission
The Philips Score is calculated for each patient by the investigator using the required data as documented in the medical records at admission
The Dakar Score is calculated for each patient by the investigator using the required data as documented in the medical records at admission
Locations(1)
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NCT07512167