RecruitingPhase 3NCT07518186

A Study Comparing JNJ-79635322 and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

A Phase 3 Randomized Study Comparing JNJ-79635322 Versus Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma After 1 to 3 Prior Lines of Therapy, Including an Anti-CD38 Antibody and Lenalidomide

Sponsor

Janssen Research & Development, LLC

Enrollment

700 participants

Start Date

May 31, 2026

Study Type

INTERVENTIONAL

Conditions

Multiple Myeloma

Summary

The purpose of this study is to evaluate how well JNJ-79635322 works when compared with teclistamab.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called JNJ-79635322 and a drug called Teclistamab for people with multiple myeloma. The study is currently recruiting participants at 29 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGJNJ-79635322

JNJ-79635322 will be administered as SC injection.

DRUGTeclistamab

Teclistamab will be administered as SC injection.

Locations(88)

Alabama Oncology

Birmingham, Alabama, United States

Mayo Clinic 1

Phoenix, Arizona, United States

Highlands Oncology Group

Springdale, Arkansas, United States

Beverly Hills Cancer Center Clinical Research Advisors LLC

Beverly Hills, California, United States

Valkyrie Clinical Trials

Los Angeles, California, United States

Mayo Clinic Jacksonville

Jacksonville, Florida, United States

Memorial Cancer Institute

Pembroke Pines, Florida, United States

Emory University

Atlanta, Georgia, United States

Franciscan Health

Indianapolis, Indiana, United States

Norton Cancer Institute

Louisville, Kentucky, United States

LSU Health Feist Weiller Cancer Center

Shreveport, Louisiana, United States

Karmanos Cancer Institute

Detroit, Michigan, United States

University Of Minnesota Medical Center

Minneapolis, Minnesota, United States

Mayo Clinic

Rochester, Minnesota, United States

Nebraska Cancer Specialists

Omaha, Nebraska, United States

Astera Cancer Care

East Brunswick, New Jersey, United States

Christus St. Vincent Regional Cancer Center

Santa Fe, New Mexico, United States

New York Oncology Hematology

Albany, New York, United States

Laura & Isaac Perlmutter Cancer Center at NYU Langone Hospital - Long Island

Mineola, New York, United States

NYU Langone Health Manhattan

New York, New York, United States

New York Cancer and Blood Specialists

Shirley, New York, United States

Gabrail Cancer Center

Canton, Ohio, United States

The Christ Hospital

Cincinnati, Ohio, United States

Bon Secours Saint Francis Cancer Center

Greenville, South Carolina, United States

Joe Arrington Cancer Research Treatment Center

Lubbock, Texas, United States

Utah Cancer Specialists

Salt Lake City, Utah, United States

St Vincent s Hospital Sydney

Darlinghurst, Australia

Beijing Chaoyang Hospital

Chaoyang District, China

Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences

Tijian, China

CHU Nantes - Hotel Dieu

Nantes, France

CHU Toulouse

Toulouse, France

CHRU de Tours

Tours, France

Universitaetsklinikum Freiburg

Freiburg im Breisgau, Germany

Asklepios Klinik Altona

Hamburg, Germany

Universitaetsklinik Tuebingen

Tübingen, Germany

Evangelismos S A

Athens, Greece

Alexandra General Hospital of Athens

Athens, Greece

University General Hospital Attikon General Hospital Of West Attica H Agia Varvara

Athens, Greece

University General Hospital of Ioannina

Ioannina, Greece

Bhagwan Mahaveer Cancer Hospital & Research Centre

Jaipur, India

Nil Ratan Sircar Medical College and Hospital

Kolkata, India

Deenanath Mangeshkar Hospital and Research Centre

Pune, India

Samson Assuta Ashdod University Hospital

Ashdod, Israel

Rambam Med.Center - Hematology Institute

Haifa, Israel

Carmel Medical Center

Haifa, Israel

Rabin Medical Center

Petah Tikva, Israel

Sheba Medical Center

Ramat Gan, Israel

Tel Aviv Sourasky Medical Center

Tel Aviv, Israel

Azienda Ospedaliero Universitaria Maggiore della Carita di Novara

Novara, Italy

Casa di Cura La Maddalena

Palermo, Italy

National Hospital Organization Kyushu Medical Center

Fukuoka, Japan

Gunma University Hospital

Gunma, Japan

University Hospital Kyoto Prefectural University of Medicine

Kyoto, Japan

Matsuyama Red Cross Hospital

Matsuyama, Japan

National Hospital Organization Okayama Medical Center

Okayama, Japan

Sapporo City General Hospital

Sapporo, Japan

The Cancer Institute Hospital of JFCR

Tokyo, Japan

Kanagawa Cancer Center

Yokohama, Japan

Pratia Onkologia Katowice

Katowice, Poland

Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli

Lublin, Poland

MTZ Clinical Research Powered by Pratia

Warsaw, Poland

Specjalistyczny Szpital im dra Alfreda Sokolowskiego w Walbrzychu

Wałbrzych, Poland

Seoul National University Bundang Hospital

Gyeonggi-do, South Korea

Chonnam National University Hwasun Hospital

Hwasun, South Korea

Asan Medical Center

Seoul, South Korea

Samsung Medical Center

Seoul, South Korea

The Catholic University of Korea Seoul St Marys Hospital

Seoul, South Korea

Hosp. Clinic de Barcelona

Barcelona, Spain

Hosp. San Pedro de Alcantara

Cáceres, Spain

Hosp Reina Sofia

Córdoba, Spain

Hosp. de Jerez de La Frontera

Jerez de la Frontera, Spain

Hosp. Univ. 12 de Octubre

Madrid, Spain

Clinica Univ. de Navarra

Pamplona, Spain

Hosp. Univ. Marques de Valdecilla

Santander, Spain

Hosp. Virgen Del Rocio

Seville, Spain

China Medical University Hospital

Taichung, Taiwan

Taichung Veterans General Hospital

Taichung, Taiwan

National Cheng Kung University Hospital

Tainan, Taiwan

National Taiwan University Hospital

Taipei, Taiwan

Taipei Veterans General Hospital

Taipei, Taiwan

Ankara University Medical Faculty

Ankara, Turkey (Türkiye)

Liv Hospital Ankara

Ankara, Turkey (Türkiye)

Memorial Antalya Hospital

Antalya, Turkey (Türkiye)

Medipol Mega University Hospital

Istanbul, Turkey (Türkiye)

Istanbul Florance Nightingale Hospital

Istanbul, Turkey (Türkiye)

Izmir Tinaztepe University Galen Hospital

Izmir, Turkey (Türkiye)

Mersin University Medical Faculty

Mersin, Turkey (Türkiye)

Ondokuz Mayis University

Samsun, Turkey (Türkiye)

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NCT07518186

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