RecruitingNot ApplicableNCT07520500

IFOC Compared With LIFT in High Anal Fistula

Early Outcomes of Intra-anal Fistulotomy With Fistula Opening Closure (IFOC) Compared With Ligation of the Intersphincteric Fistula Tract (LIFT) in High Anal Fistula: A Pilot Randomized Controlled Trial


Sponsor

Cairo University

Enrollment

66 participants

Start Date

Mar 31, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

Patients presenting to the outpatient clinic at Kasr Al-Ainy Hospitals with high anal fistula will be assessed according to the inclusion and exclusion criteria. The study purpose will be explained, and informed consent will be obtained from eligible participants. A detailed medical history and routine preoperative assessment will be conducted. Clinical evaluation will include identification of the internal and external openings, assessment of discharge, and continence status using the Jorge-Wexner incontinence score. MRI fistulogram will be performed preoperatively to evaluate the fistula tract and its relation to the sphincter complex. Patients will be randomly allocated into two equal groups (1:1 ratio) using a computer-generated sequence: Group A: Undergo LIFT procedure Group B: Undergo IFOC procedure Both procedures will be performed as per standard surgical techniques. Postoperatively, patients will start oral fluids after 2 hours and resume a normal diet as tolerated. Discharge is planned on the first postoperative day unless otherwise indicated. Follow-up will be conducted at 1 week, 2 weeks, 1 month, and monthly thereafter for at least 6 months to assess healing and detect complications, including recurrence.


Eligibility

Min Age: 18 Years

Inclusion Criteria1

  • Patients with high anal fistula from both gender

Exclusion Criteria5

  • Patient with preoperative fecal incontinence
  • Fistula secondary to colorectal malignancy
  • Patients with inflammatory bowel disease
  • Fistula secondary to trauma or radiation
  • Low anal fistula

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Interventions

PROCEDUREIntra-anal Fistulotomy With Fistula Opening Closure (IFOC)

The fistulous tract was identified using an arterial clamp and confirmed by water injection. Intra-anal fistulotomy was performed with electrocautery, followed by curettage of granulation tissue. The internal opening was closed with absorbable sutures in a horizontal mattress fashion, with closure confirmed by water injection. The external tract was further curetted, a tube drain was inserted, and reinforcing sutures were applied to promote healing.

PROCEDURELigation of the Intersphincteric Fistula Tract (LIFT)

The internal opening was identified by injection through the external opening. The tract was dissected in the intersphincteric plane, ligated at two points, and divided. Closure was confirmed by reinjection, the external opening was curetted and drained, and the incision was loosely closed.


Locations(1)

Faculty of medicine, Cairo University

Cairo, Al-Manial, Cairo, Egypt, Egypt

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NCT07520500


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