RecruitingNot ApplicableNCT07524400

Effects of Physical Exercise Combined With Transcranial Direct Current Stimulation in Parkinson's Disease

Effects of the Combination of Physical Exercise and Transcranial Direct Current Stimulation on Motor Function and Underlying Neurophysiological Mechanisms in Parkinson's Disease

Sponsor

Universidad Rey Juan Carlos

Enrollment

100 participants

Start Date

May 10, 2026

Study Type

INTERVENTIONAL

Conditions

Parkinson Disease

Summary

A controlled, blinded, and randomized clinical study will be carried out in a large sample of people with Parkinson's disease, where the combined effects of physical exercise and transcranial direct curren stimlation (tDCS) on motor function will be evaluated.

Eligibility

Inclusion Criteria3

Clinical diagnosis of idiopathic Parkinson's disease, established according to the UK Parkinson's Disease Society Brain Bank Criteria.
Ability to understand and comply with study procedures.
Stable antiparkinsonian medication regimen prior to study participation.

Exclusion Criteria15

Significant cognitive impairment, defined as a score < 23 on the Mini-Mental State Examination (MMSE).
Below-average premorbid intelligence, defined as a score < 40 on the Vocabulary subtest of the Wechsler Adult Intelligence Scale - Third Edition (WAIS-III).
Clinically significant depression, defined as a score > 10 on the Geriatric Depression Scale (GDS-15).
Current treatment with cholinesterase inhibitors.
Presence of severe cardiovascular disease, including but not limited to:
Congestive heart failure
Ischemic heart disease
Cardiac pacemaker
Orthostatic hypotension
Uncontrolled diabetes mellitus.
History of stroke or traumatic brain injury.
History of seizure disorder or epilepsy.
Presence or prior implantation of a deep brain stimulation (DBS) device.
History of major orthopedic surgery that could interfere with motor performance or gait.
Presence of implanted electronic devices, including cardiac pacemakers, incompatible with study procedures.