Impact of Theta Burst Repetitive Transcranial Magnetic Stimulation on the Patient's Self-reported Improvement in Their Motor Functional Neurological Disorder
Hospital Center Guillaume Régnier
22 participants
Mar 13, 2026
OBSERVATIONAL
Conditions
Summary
Functional neurological disorder (FND) is a condition that causes significant suffering and disability. It is defined by the presence of neurological symptoms that interfere with an individual's functioning and are not consistent with any known anatomical lesion but that causes significant functional impairment. The investigators are particularly interested in motor symptoms (abnormal movements or motor deficits). Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive and acceptable treatment that has proven effective in certain chronic pain conditions, depression, and OCD. The investigators would like to evaluate the impact of rTMS on the patient's overall perception of change, particularly on the clinical symptoms of motor FND. Secondary objectives include evaluating the overall effect on symptoms from the clinician's perspective, the effect on quality of life, on depressive and anxiety symptoms and associated dissociation, as well as evaluating any changes in the sense of agency and identifying the side effects of rTMS treatment.
Eligibility
Inclusion Criteria4
- Patients over 18
- Patients with FND, either deficits or abnormal movements, diagnosed by a neurologist.
- Patients with an indication for validated neuronavigated rTMS treatment.
- Patients who have indicated that they do not object to participating in the study.
Exclusion Criteria2
- Patients subject to legal protection (legal guardianship, conservatorship, trusteeship)
- Patients deprived of liberty
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Interventions
Patients receive 40 sessions of intermittent theta burst stimulation of the right TPJ over 10 days (4 sessions per day). The right TPJ is located using neuronavigation.
Locations(1)
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NCT07527403