RecruitingPhase 3NCT07528027
Phase III Study of HRS-7535 for Hypertension With Overweight or Obesity
A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Clinical Study to Evaluate the Efficacy and Safety of HRS-7535 for the Treatment of Hypertension in Participants With Obesity or Overweight
Sponsor
Shandong Suncadia Medicine Co., Ltd.
Enrollment
648 participants
Start Date
May 29, 2026
Study Type
INTERVENTIONAL
Conditions
Summary
The main objective of this study is to demonstrate the superior efficacy of HRS-7535 in controlling blood pressure compared to placebo in subjects with hypertension and overweight or obesity;
Eligibility
Min Age: 18 YearsMax Age: 70 Years
Inclusion Criteria4
- On the day of signing the informed consent form, the age should be between 18 and 70 years old, with no gender restrictions;
- When screening or randomizing, the average office blood pressure meets any of the following conditions: ① 140 mmHg ≤ SBP < 170 mmHg, and DBP < 110 mmHg; ② 90 mmHg ≤ DBP < 110 mmHg, and 130 mmHg ≤ SBP < 170 mmHg;
- Patients with untreated hypertension, or those who have received stable doses of any or all of the following classes of antihypertensive medications within 30 days prior to screening: 1) angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARB), 2) thiazides and thiazide-like diuretics, 3) calcium channel blockers. Patients who are currently receiving stable doses of beta blockers (such as metoprolol or atenolol) or mineralocorticoid receptor antagonists (such as spironolactone) and intend to continue these treatments at their current doses may be included in this study;
- During screening, BMI should be ≥24 kg/m2;
Exclusion Criteria5
- Having a known secondary cause of hypertension
- History of previously diagnosed heart failure with reduced ejection fraction (HFrEF);
- Those who have undergone coronary revascularization within the previous 90 days or plan to undergo it during the trial period;
- Diagnosed or suspected with type 1 diabetes, special type of diabetes, or secondary diabetes (excluding gestational diabetes);
- History of acute or chronic pancreatitis, pancreatic injury, acute cholecystitis, or symptomatic/requiring treatment of gallbladder disease (excluding those who have undergone cholecystectomy but are still eligible for enrollment as determined by the investigator);
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Interventions
DRUGHRS-7535
HRS-7535
DRUGPlacebo
Placebo
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07528027