Novel 3-dimensional Echocardiographic Quantification of Mitral Regurgitant Volume
Germans Trias i Pujol Hospital
200 participants
Mar 17, 2026
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is demonstrate that a novel artificial intelligence based software for the quantification of the mitral regurgitation on 3-dimensional transesophageal echocardiography (3D CFQ) is more reproducible and accurate than the conventional assessment of mitral regurgitation performed with 2-dimensional echocardiography. The main question aims to answer is to demonstrate the agreement between 3D-CFQ measurement of the mitral regurgitant volume and the cardiac magnetic resonance measurement of the regurgitant volume is better than the agreement between 2-dimensional echocardiography and cardiac magnetic resonance. If this is demonstrated, we would like to test the accuracy of this tool to be applied in acute settings such as transcatheter interventions to decide the therapy to follow. Participants will undergo clinically indicated transesophageal echocardiography to characterize the mechanism and severity of mitral regurgitation and to cardiac magnetic resonance to be used as reference stadard to define the mitral regurgitation severity.
Eligibility
Inclusion Criteria2
- Patients with at least moderate mitral regurgitation of any etiology
- Patients with good transesophageal echocardiography image quality
Exclusion Criteria2
- Patients with prior transcatheter or surgical mitral valve intervention
- Patients with contraindications for transesophageal echocardiography or cardiac magnetic resonance
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Interventions
The analysis of mitral regurgitation in current practice is based on multiparametric approach of several 2-dimensional Doppler echocardiographic parameters and quantification of mitral regurgitant volume and effective regurgitant orifice area measured with the proxymal isovelocity surface area. This novel algorithm based on artificial intelligence based software may change clinical practice if demonstrates that provides more accurate estimation of the severity of mitral regurgitation.
Locations(1)
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NCT07528781