HBV Reactivation in Immunocompromised Patients (REANT STUDY)
Management and Monitoring of HBV Reactivation in Immunocompromised Patients in Turkey (REANT STUDY)
Yaşar Bayındır, MD
490 participants
Mar 9, 2026
OBSERVATIONAL
Conditions
Summary
Background/Objective: Comorbidities represent a critical risk factor in the prognosis of patients receiving immunosuppressive therapy. For patients with anti-HBc IgG positivity requiring Hepatitis B virus (HBV) prophylaxis, the long-term physiological impact of oral antivirals remains a concern. This study aims to prospectively monitor bone, renal, and metabolic dysfunctions associated with oral antiviral use and other systemic risk factors over a long-term period. Methods: The REANT Cohort is designed as a 4-year, multicenter prospective study. The cohort will consist of patients initiated on HBV prophylaxis due to immunosuppressive treatment. Participants will undergo regular longitudinal assessments to evaluate bone mineral density, renal filtration and tubular functions, and metabolic profiles. The interplay between antiviral therapy, baseline comorbidities, and long-term organ dysfunction will be analyzed. Conclusion: The findings from the REANT Cohort are expected to provide robust evidence regarding the safety of long-term HBV prophylaxis and assist in the development of monitoring guidelines for immunosuppressed patients with latent HBV infection.
Eligibility
Plain Language Summary
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Interventions
Patients who take all antivirals recommended in the guidelines will be evaluated in the same group.
Locations(16)
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NCT07529171