HUMSCs Combined With Col I to Third-Degree Burn Wound
A Single-Center, Randomized, Double-Blind, Placebo-Controlled Exploratory Clinical Study of Human Umbilical Cord Mesenchymal Stem Cells Combined With Bovine Type I Collagen for Promoting Third-Degree Burn Wound Repair
The First Affiliated Hospital of Xinxiang Medical College
108 participants
Apr 6, 2026
INTERVENTIONAL
Conditions
Summary
To evaluate the safety and tolerability of human umbilical cord mesenchymal stem cells combined with bovine type I collagen in the treatment of third-degree burn wounds.
Eligibility
Inclusion Criteria5
- Aged 18-65 years, gender unrestricted
- Confirmed third-degree burns, wound area 1%-5% TBSA
- Admission within 72 hours after burn injury
- Voluntarily signed informed consent
- Able to cooperate and complete follow-up
Exclusion Criteria8
- Pregnant or lactating females
- Severe immunodeficiency or autoimmune disease
- History of malignant tumor, or coagulation dysfunction
- Severe cardiac, hepatic, or renal insufficiency
- Hypersensitivity to collagen or stem cell components
- Uncontrollable severe wound infection
- Participation in other clinical studies within the past 3 months
- Inability to comply with follow-up
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Interventions
To evaluate the safety and tolerability of human umbilical cord mesenchymal stem cells combined with bovine type I collagen in the treatment of third-degree burn wounds
To evaluate the safety and tolerability of bovine type I collagen in the treatment of third-degree burn wounds
To evaluate the safety and tolerability of sterile blank dressing / vaseline gauze in the treatment of third-degree burn wounds.
Locations(1)
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NCT07530003