A Clinical Study of Ulonivirine (MK-8507) With Atorvastatin and Metformin in Healthy Adults (MK-8507-018)
A Phase 1, Open-Label, Two-Period Fixed Sequence Study to Evaluate the Effects of a Single Oral Dose of Ulonivirine (MK-8507) on the Single-Dose Pharmacokinetics of Atorvastatin and Metformin in Healthy Adult Participants
Merck Sharp & Dohme LLC
12 participants
Apr 29, 2026
INTERVENTIONAL
Conditions
Summary
Researchers want to learn about ulonivirine when given with atorvastatin and metformin in healthy people. The goal of this study is to compare the amount of atorvastatin and metformin in a person's body over time when given with and without ulonivirine.
Eligibility
Inclusion Criteria2
- Has body mass index (BMI) 18.0 and ≤ 32.0 kg/m\^2
- Is medically healthy with no clinically significant medical history, physical examination, clinical laboratory profiles, vital signs, and electrocardiogram (ECG)
Exclusion Criteria2
- Has history of cancer (malignancy)
- Positive results for human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), or hepatitis C virus (HCV)
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Interventions
Oral tablet
Oral tablet
Oral tablet
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07530289