RecruitingNot ApplicableNCT07532460

The Role of Potassium Channels in Working Memory Impairments of Chronic Cocaine Users

Randomised, Double-Blind, Placebo-Controlled, Crossover Study Investigating the Role of Potassium Channels in Working Memory Impairments of Chronic Cocaine Users


Sponsor

Boris Quednow

Enrollment

40 participants

Start Date

May 28, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The study aims to address the neurobiological basis of cognitive impairments in chronic cocaine users by investigating the potential impact of an acute potassium channel blockade on working memory performance and other cognitive functions.


Eligibility

Min Age: 20 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called 4-aminopyridine (4-AP) and a drug called Placebo for people with cocaine use disorder (cud) and cognitive impairments. The study is currently recruiting participants at 1 location. People eligible for this study include aged 20 Years to 50 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUG4-aminopyridine (4-AP)

Two doses of fampridine administered during one of the two experimental test sessions.

DRUGPlacebo

Matching placebo administered during one of the two experimental test sessions.


Locations(1)

University Hospital of Psychiatry Zurich

Zurich, Canton of Zurich, Switzerland

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NCT07532460


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