RecruitingPhase 1NCT07532902

A Study of BMS-986504 With Standard-of-Care Therapy for People With Solid Tumor Cancer

A Phase 1a/1b Basket Trial of BMS-986504 With Standard-of-Care Therapy For Patients With Select Metastatic MTAP-deleted Solid Tumors


Sponsor

Memorial Sloan Kettering Cancer Center

Enrollment

60 participants

Start Date

Apr 7, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The researchers are doing this study to test the safety of BMS-986504 in combination with standard disease-specific anticancer medication in people with metastatic/advanced unresectable MTAP-deleted solid tumor cancer.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called 5-FU, a drug called BMS-986504, and others for people with diffuse pleural mesothelioma, gastroesophageal carcinoma, and other related conditions. The study is currently recruiting participants at 7 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGBMS-986504

BMS-986504 PO daily

DRUGIpilimumab

Ipilimumab (1mg/kg Q6wk)

DRUGNivolumab

Nivolumab (360mg flat dose Q3wk)

DRUG5-FU

are continued until disease progression or intolerance

DRUGLeucovorin

are continued until disease progression or intolerance

DRUGOxaliplatin

are continued until disease progression or intolerance

DRUGGemcitabine

Gemcitabine are given for a maximum of 6 cycles

DRUGPlatinum

Platinum are given for a maximum of 6 cycles


Locations(7)

Memorial Sloan Kettering Basking Ridge (All Protocol Activities)

Basking Ridge, New Jersey, United States

Memorial Sloan Kettering Monmouth (All Protocol Activities)

Middletown, New Jersey, United States

Memorial Sloan Kettering Bergen (All Protocol Activities)

Montvale, New Jersey, United States

Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities)

Commack, New York, United States

Memorial Sloan Kettering Westchester (All Protocol Activities)

Harrison, New York, United States

Memorial Sloan Kettering Cancer Center (All Protocol Activities)

New York, New York, United States

Memorial Sloan Kettering Nassau (All Protocol Activities)

Uniondale, New York, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07532902


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