RecruitingNCT07535619

The Voided Urinary, Perineal, and Faecal Microbiota Among Children and Adolescents - the PpUF-study.

The Voided Urinary, Perineal, and Faecal Microbiota Among Children and Adolescents With Overactive Bladder and Daytime Urinary Incontinence and Healthy Children and Adolescents - the PpUF-study.

Sponsor

Aalborg University Hospital

Enrollment

110 participants

Start Date

Dec 14, 2022

Study Type

OBSERVATIONAL

Conditions

Urinary Incontinence Lower Urinary Tract Symptoms Urologic Diseases Behavioral Symptoms Urological Manifestations Daytime Wetting Urination Disorders Elimination Disorders

Summary

The aim of this study is to investigate whether the voided urinary, perineal/preputial, and the fecal microbiota are different between children suffering from Overactive Bladder (OAB) and Daytime Urinary Incontinence (DUI) compared to age- and gender-matched healthy children without bladder symptoms. Moreover, the study aims to investigate if the microbiota is different according to the severity of DUI and if the microbiota is changed throughout treatment of DUI. A follow-up study will as well be performed on healthy children to investigate how the microbiota evolves with increasing age and pubertal stage. Children with OAB and DUI will be recruited from involved pediatric departments, and specimen in the form of urine, perineal/preputial swabs, and feces will be collected according to the protocol.

Eligibility

Min Age: 5 YearsMax Age: 17 Years

Inclusion Criteria5

Overactive bladder as per International Children's Continence Society criteria (cases only).
At least two wet days per week (cases only).
No prior pharmacological treatment of OAB and DUI (cases only).
No lower urinary tract symptoms (healthy participants only).
Negative urine dipstick test