Antihistamine for Prevention of HTR After Blood Primed CPB
Prophylactic Antihistamine for Prevention of Hypotensive Transfusion Reaction After Blood Primed Cardiopulmonary Bypass in Pediatric Cardiac Surgery: a Randomized-controlled Study
Kasr El Aini Hospital
40 participants
Mar 1, 2026
INTERVENTIONAL
Conditions
Summary
This study will be a randomized, double-blinded, placebo-controlled study conducted at a university hospital. Forty children undergoing elective repair of a congenital heart defect will be included. The patients will be randomly allocated (20 patients per group) to receive a single intravenous dose of combined chlorpheniramine or normal saline immediately after separation from CPB, before protamine administration.
Eligibility
Inclusion Criteria3
- Acyanotic congenital heart disease.
- Age :1 -7 years.
- Genre: both.
Exclusion Criteria4
- Redo patient.
- History of allergy to antihistamines.
- Bleeding disorders with INR > 1.5 and/or platelets < 50,000.
- Emergency procedure.
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Interventions
chlorpheniramine 0.25 mg/Kg in 2 ml immediately after separation from CPB, before protamine administration
equal volume normal saline
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07536152