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RecruitingNot ApplicableNCT07538388

Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension

Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension in High-Risk Non-Cardiac Surgery Patients - The Multicenter INDUCT Trial (INDUCT-Multi)

Sponsor

Universitätsklinikum Hamburg-Eppendorf

Enrollment

446 participants

Start Date

May 7, 2026

Study Type

INTERVENTIONAL

Conditions

Postinduction Hypotension

Summary

INDUCT-Multi is a multicenter randomized trial investigating whether continuous, compared to bolus, administration of norepinephrine during induction of general anesthesia reduces postinduction hypotension in high-risk non-cardiac surgery patients.

Eligibility

Min Age: 45 Years

Inclusion Criteria7

  • We will include consenting patients ≥45 years scheduled for elective major non-cardiac surgery under general anesthesia with planned continuous intra-arterial blood pressure monitoring with a radial arterial catheter and with at least two of the following risk criteria for developing acute kidney injury:
  • Age ≥65 years
  • ASA physical status III or IV
  • Chronic arterial hypertension
  • Diabetes mellitus requiring medication
  • Intra-abdominal surgery
  • Preoperative renal insufficiency (serum creatinine ≥1.2 mg/dL)

Exclusion Criteria5

  • Pregnancy
  • Cardiac arrhythmia
  • History of intracranial hemorrhage or intracranial aneurysm
  • Clinical indication for continuous norepinephrine infusion during induction of general anesthesia (e.g., severe aortic valve stenosis, coronary artery disease, or heart failure)
  • Patients who are unable to understand, read, and provide informed consent in German

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Interventions

PROCEDUREContinuous Norepinephrine Administration

In patients assigned to continuous administration of norepinephrine, a syringe infusion pump will be prepared and connected to a peripheral or central venous catheter. The responsible anesthesiologist will start the norepinephrine infusion and adjust the infusion rate as necessary and may administer additional norepinephrine boluses via the syringe infusion pump if required.

Locations(4)

Department of Anesthesiology, University Hospital Duesseldorf, Heinrich Heine University Duesseldorf

Düsseldorf, Germany

Department of Anaesthesiology, Intensive Care Medicine and Pain Medicine, University Hospital Giessen, Justus-Liebig University Giessen

Giessen, Germany

Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf

Hamburg, Germany

Department of Anaesthesiology, University Hospital LMU Munich

München, Germany

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NCT07538388