RecruitingPhase 4NCT07544251

Comparing Sarecycline and Doxycycline Effects on the Skin and Gut Bacteria in Acne.

The Effects of Sarecycline Versus Doxycycline on the Gut Microbiome and Skin Microbiome in Acne.

Sponsor

Integrative Skin Science and Research

Enrollment

30 participants

Start Date

Apr 20, 2026

Study Type

INTERVENTIONAL

Conditions

Acne vulgaris

Summary

This study is being done to help better understand how the gut and skin bacteria of the body change when people with acne are treated with Sarecycline or Doxycycline. The bacteria in the gut and on the skin will be studied to see how each treatment may affect them and whether they change the profile of the bacteria that is present.

Eligibility

Min Age: 9 Years

Inclusion Criteria3

\) Diagnosis of acne vulgaris with:
At least 10 inflammatory lesions (papules, pustules, and nodules) up to 100 noninflammatory lesions (open and closed comedones)
No more than 2 nodules on the face

Exclusion Criteria18

Dermatological condition of face or facial hair that could interfere with clinical evaluations
Subjects who have used the following medications (topical refers only to the facial area) will not be eligible:
a) Within 2 week prior to randomization:
Topical acne medications such as retinoids, antibiotics, hormonal modulators
Topical benzoyl peroxide
Topical anti-inflammatories and corticosteroids
b) Within 4 weeks prior to randomization:
Systemic antibiotics
Systemic acne treatments
Oral probiotic supplement
Systemic corticosteroids
c) Within 12 weeks prior to randomization:
Systemic retinoids
\) Individuals who have changed any of their hormonal based contraception or therapies within 3 months prior to joining the study.
\) Individuals who are pregnant or breastfeeding.
\) Individuals on oral contraceptive pills or progesterone or estrogen containing therapies unless they have been on a stable dose for 2 months.
\) Individuals on finasteride or dutasteride
\) Current tobacco smoker or a tobacco smoking history that is greater than 5 pack-years.

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Interventions

DRUGSarecycline

One tablet by mouth (weight based dosing at 1.5 mg/kg and rounded to the closest tablet dose at either 60 mg, 100mg, or 150 mg tablet) once a day with food and a full glass of water (about 8 ounces)

DRUGDoxycycline

100 mg twice daily with food and a full glass of water (about 8 ounces)