RecruitingNot ApplicableNCT07548424

Study of a Peptide Cream's Effect on the Facial Skin Barrier Using a Side-by-Side Comparison

Evaluation of the Effect of a Topical Formulation Containing Acetyl Hexapeptide-37 on Objective Skin Barrier Parameters of the Face in a Randomized Controlled Split-Face Design


Sponsor

University of Split, School of Medicine

Enrollment

30 participants

Start Date

May 1, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to evaluate whether a topical face cream containing the peptide Acetyl Hexapeptide-37 improves skin hydration and strengthens the skin barrier compared to a placebo cream in healthy adult participants. The study uses a split-face design, in which one side of the face is treated with the peptide cream and the other side with a placebo (a cream without the active ingredient). The main questions it aims to answer are: * Does the peptide cream improve skin hydration and reduce transepidermal water loss compared to placebo? * Does the peptide cream affect skin erythema or cause irritation? * How do participants rate the comfort and tolerability of the peptide cream? Researchers will compare the treated and placebo sides of the face to assess differences in skin barrier function and tolerability. Participants will: * Attend a baseline visit for assessment of facial skin parameters, including hydration, transepidermal water loss, and erythema * Apply the peptide cream to one side of the face and the placebo cream to the other side once daily for 4 weeks * Attend weekly follow-up visits for non-invasive skin measurements * Record any skin sensations (e.g., stinging, tightness) or adverse effects throughout the study


Eligibility

Min Age: 18 YearsMax Age: 50 Years

Inclusion Criteria1

  • healthy volunteers who gave written informed consent

Exclusion Criteria4

  • presence of active skin diseases or dermatological conditions
  • known allergy or hypersensitivity to any ingredient of the study products
  • pregnancy or breastfeeding
  • use of topical or systemic corticosteroids, immunosuppressive drugs, or antihistamines prior to or during the study

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Interventions

OTHERAcetyl Hexapeptide-37 Cream

Topical emollient cream containing Acetyl Hexapeptide-37 as the active ingredient, applied once daily to one side of the face for 4 weeks.

OTHERPlacebo Cream

Topical emollient cream identical in composition to the investigational product but without Acetyl Hexapeptide-37, applied once daily to the contralateral side of the face for 4 weeks.


Locations(1)

University of Split School of Medicine

Split, Croatia

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NCT07548424


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