RecruitingNot ApplicableNCT07551245

Knee Osteoarthritis Rehab: High-Intensity Laser vs Classical Modalities

Rehabilitation of Knee Osteoarthritis by High Intensity Laser Therapy vs Classical Modalities

Sponsor

Erbil Polytechnic University

Enrollment

100 participants

Start Date

Apr 20, 2026

Study Type

INTERVENTIONAL

Conditions

Knee Arthritis, Osteoarthritis

Summary

This study aims to compare the effectiveness and safety of High-Intensity Laser Therapy (HILT) with conventional physical therapy treatments in patients with knee osteoarthritis. Knee osteoarthritis is a common condition, especially in older adults, causing pain, stiffness, reduced movement, and difficulty performing daily activities. Current treatments focus on reducing pain and improving joint function. In this study, 100 patients with knee osteoarthritis will be divided into two groups. One group will receive HILT combined with therapeutic exercises, while the other group will receive conventional physical therapy modalities along with the same exercises. The treatment outcomes will be evaluated over time. The main outcomes include pain reduction (measured by pain scales such as WOMAC and VAS), improvement in joint function, and structural changes in the knee assessed by MRI. In addition, laboratory tests will be used to measure inflammation, cartilage health markers, and oxidative stress before and after treatment. The goal is to determine whether HILT provides better pain relief, improves joint function, and is safe compared to standard therapy. The results may help improve rehabilitation strategies for patients with knee osteoarthritis.

Eligibility

Min Age: 30 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a medical device called Conventional Physical Therapy Modalities and a medical device called High-Intensity Laser Therapy (HILT) for people with knee arthritis, osteoarthritis. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEHigh-Intensity Laser Therapy (HILT)

High-Intensity Laser Therapy (HILT) combined with therapeutic exercise program. HILT Specifications: * Four-wavelength beam system for deep tissue penetration * Continuous and modulating frequencies to promote pain control and healing * SuperPulse mode for deeper therapeutic penetration * High power output delivering larger doses with shorter treatment times * Pre-programmed presets for consistent and safe treatment outcomes Mechanism of Action: HILT delivers high energy output into tissues, generating photochemical effects including: * Increased mitochondrial oxidation and ATP production * Enhanced blood circulation and metabolism * Fast absorption of edema and removal of exudates * Increased serotonin and endorphin levels * Anti-inflammatory effects through reduced prostaglandin synthesis * Decreased nerve cell membrane permeability for Na/K causing hyperpolarization * Increased lymphatic flow * Modulation of genetic markers: increased expression of cartilage protection biomarkers

DEVICEConventional Physical Therapy Modalities

Classical Physical Modalities combined with therapeutic exercise program. Modalities Include: * Therapeutic Ultrasound and/or other conventional physical therapy modalities as per standard clinical practice for knee osteoarthritis * Evidence-based parameters for knee OA treatment Treatment Protocol: * Duration: 8 weeks * Combined with the same standardized therapeutic exercise program as the HILT group * Sessions will be conducted at rheumatology and rehabilitation units in Erbil, Iraq This represents the current standard of care for conservative management of knee osteoarthritis in physical medicine and rehabilitation settings.