RecruitingPhase 2NCT07560020

A Trial to Compare Treatment With Surlorian (ARM210, S48168) to Placebo in Effects on Muscle Strength and Safety in Adults With Autosomal Dominant RYR1-related Myopathy

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial to Assess the Efficacy and Safety of Surlorian (ARM210, S48168) in Adults With Autosomal Dominant RYR1-Related Myopathy


Sponsor

RyCarma Therapeutics, Inc.

Enrollment

28 participants

Start Date

Jul 1, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This study is testing a medicine called surlorian in adults who have a genetic muscle condition known as autosomal dominant RYR1-related myopathy (RYR1-RM). The goal is to find out whether surlorian improves muscle weakness, and whether it is safe and well tolerated.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Placebo and a drug called Surlorian for people with autosomal dominant ryr1-related myopathy. The study is currently recruiting participants at 9 locations. People eligible for this study include aged 18 Years to 65 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSurlorian

300 mg administered once a day

OTHERPlacebo

administered once a day


Locations(9)

AP-HM- Hôpital de La Timone

Marseille, Bouches-du-Rhône, France

Institut de Myologie - Hôpital de La Pitié-Salpétrière

Paris, France

Universitätsklinikum Ulm

Ulm, Baden-Wurttemberg, Germany

Charité - Campus Berlin Buch

Berlin, State of Berlin, Germany

Radboud Universitair Medisch Centrum

Nijmegen, Gelderland, Netherlands

Hospital Universitario Vall d'Hebron - PPDS

Barcelona, Barcelona, Spain

Hospital Universitario de Donostia

San Sebastián, Guipúzcoa, Spain

The Robert Jones and Agnes Hunt Orthopaedic Hospital

Oswestry, Shropshire, United Kingdom

University College Hospital - PPDS

London, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT07560020