Comparison of Topical Insulin and Amniotic Membrane Transplant for Persistent Corneal Epithelial Defects
Comparison of Efficacy of Topical Insulin With Amniotic Membrane Transplant in Persistent Epithelial Defects of Cornea
Al-Shifa Trust Eye Hospital
214 participants
Mar 27, 2026
INTERVENTIONAL
Conditions
Summary
After an initial period of standard treatment, they received further care aimed at helping the surface of the eye heal. Clear instructions were given on how to use and store the treatment properly. Patients were then monitored regularly over several months, with doctors checking their healing progress during follow-up visits. The study continued for a total of 24 weeks to observe how well and how quickly the eye surface recovered.
Eligibility
Inclusion Criteria1
- Corneal epithelial defects for more than 2 weeks no improvement using standard treatment
Exclusion Criteria4
- Systemic conditions e.g. uncontrolled Diabetes, autoimmune disorders
- Recent eye surgery within last 3 months
- Hereditary corneal dystrophies
- Active eye infections
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Interventions
Topical Insulin eye drops will be administered every 6 hours till healing of corneal epithelial defects
Surgically amniotic membrane grafts will be applied to bridge and heal the corneal defects
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07561398