COmparison of Maintenance of Propofol And Sevoflurane Spectral Study
Comparison of EEG Power Spectrum During Maintenance of Anesthesia With Propofol Versus Sevoflurane
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
280 participants
Apr 13, 2026
INTERVENTIONAL
Conditions
Summary
Lower EEG alpha band power is currently extensively studied as a potential biomarker of brain vulnerability. No previous study has evaluated whether there was a difference in EEG power spectrum ranges between propofol and sevoflurane, the two main anesthetic agents for maintenance of general anesthesia, in order to define a cut-off value for the prediction of a higher risk of postoperative delirium. * Primary objective: comparison of EEG alpha power (dB) during maintenance of anesthesia with propofol and sevoflurane using data available in the NeuroSense® depth-of-anesthesia monitoring * Secondary objectives: comparison of other EEG frequency bands during maintenance of anesthesia with propofol and sevoflurane using data from the NeuroSense® depth-of-anesthesia monitoring
Eligibility
Inclusion Criteria2
- Capable to give informed consent
- French-speaking patients
Exclusion Criteria8
- Need for a premedication with benzodiazepine before anesthesia
- Reduced left ventricular ejection fraction (< 50%) or underlying cardiac pathology requiring a more balanced anesthesia (administration of benzodiazepine and/or ketamine during anesthesia)
- Preoperative MoCA score < 26/30 (for patients > ou = 55 years old)
- Patients treated with anti-epileptic drugs
- Patients treated with benzodiazepines (ex: for anxiolysis or sleep disorders)
- Emergencies
- Morbid obesity (BMI > 40kg/m2)
- Background of severe postoperative nausea/vomit
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Interventions
Maintenance of general anesthesia for simple electrophysiological procedures
Maintenance of general anesthesia for simple electrophysiological procedures
Locations(1)
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NCT07561970