RecruitingNot ApplicableNCT07563036

JAK2 Expression in Androgenetic Alopecia Before and After Topical Minoxidil

Assessment of Janus Kinase 2 Expression in Patients With Androgenic Alopecia and Its Modulation by Topical Minoxidil Therapy.

Sponsor

Kasr El Aini Hospital

Enrollment

25 participants

Start Date

Feb 1, 2026

Study Type

INTERVENTIONAL

Conditions

androgenetic alopecia Androgenic alopecia

Summary

Androgenetic alopecia is a common form of progressive hair loss. This prospective single-arm pre-post interventional study aims to assess tissue Janus Kinase 2 (JAK2) expression in patients with androgenetic alopecia by comparing balding and non-balding scalp at baseline, and to evaluate changes in JAK2 expression in balding scalp after 3 months of topical minoxidil 5% therapy. Clinical response will be assessed using standardized trichoscopic parameters.

Eligibility

Sex: MALEMin Age: 18 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a procedure called Scalp Punch Biopsy, Tissue JAK2 Protein Measurement by ELISA, and others for people with androgenic alopecia and androgenetic alopecia. The study is currently recruiting participants at 1 location. People eligible for this study include men aged 18 Years to 50 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGTopical Minoxidil 5% Solution

Topical minoxidil 5% solution applied to the affected scalp areas for 12 weeks. Men will apply 1 cc twice daily and women will apply 1 cc once daily.

PROCEDUREScalp Punch Biopsy

Three 2 mm punch biopsies will be obtained during the study: one from the balding scalp area and one from the non-balding scalp area at baseline, and one from the balding scalp area after 12 weeks of treatment.

DIAGNOSTIC_TESTTissue JAK2 Protein Measurement by ELISA

Tissue samples obtained from scalp punch biopsies will be analyzed for Janus Kinase 2 (JAK2) protein levels using ELISA at baseline and after 12 weeks of treatment.