RecruitingPhase 1NCT07566585

Dose Finding Study to Evaluate the Safety of BSB-2002 in Relapsed or Refractory Acute Myeloid Leukemia (AML) Patients With NPM1 Mutation

A Phase 1 Multicenter Dose Finding Study to Evaluate the Safety of BSB-2002 in Relapsed or Refractory Acute Myeloid Leukemia (AML) Patients With NPM1 Mutation


Sponsor

BlueSphere Bio, Inc

Enrollment

19 participants

Start Date

Apr 21, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to test BSB-2002 which is a new type of cellular therapy to treat blood cancer (AML). It will evaluate the safety of BSB-2002 and also determine whether it works to prevent relapse of your cancer.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called SOC+ BSB-2002 and a drug called SOC+BSB-2002 for people with aml (acute myeloid leukemia), aml with mutated npm1, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSOC+ BSB-2002

Patients will receive BSB-2002 as a single IV infusion at day 1 following the lymphodepletion regime.

DRUGSOC+BSB-2002

Patients will receive BSB-2002 as a single IV infusion at day 1 following the lymphodepletion regime.


Locations(1)

Washington University at St Louis

St Louis, Missouri, United States

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NCT07566585


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