Auditory EEG and Behavioral Assessments in Individuals With Rett Syndrome
University of Rochester
60 participants
Jul 31, 2025
OBSERVATIONAL
Conditions
Summary
This observational research study is designed to learn more about how the brain processes sound in individuals with Rett syndrome. Participants will complete a noninvasive electroencephalogram (EEG) recording while listening to simple sounds through headphones. In addition, parents or caregivers will complete questionnaires and an interview about the participant's symptoms, communication abilities, daily functioning and overall health. The information collected from this study may help researchers better understand brain activity patterns and clinical features associated with Rett syndrome and support future research efforts.
Eligibility
Inclusion Criteria9
- Rett Syndrome Participants:
- Have a clinical diagnosis of classic Rett syndrome
- Have a pathogenic MECP2 genetic variant confirmed via genetic testing
- Are past the clinical regression stage
- Are within the eligible age range for the study (2 years or older)
- Are able to tolerate the noninvasive EEG recording
- Parent or caregiver is willing and able to provide parental permission and complete questionnaires and interviews
- Neurologically healthy individuals ages 2 years or older
- Are able to tolerate the noninvasive EEG recording
Exclusion Criteria10
- Experiences hearing impairment or hearing loss
- Presence of medical conditions that would prevent safe participation in EEG recording
- Inability to tolerate EEG procedures
- Any condition that in the opinion of the investigator would interfere with study participation or data quality
- Controls
- Experiences hearing impairment or hearing loss
- Medical history of genetic, neurological, or psychiatric disorders
- History of special education services
- Inability to tolerate EEG procedures
- Any condition that in the opinion of the investigator would interfere with study participation or data quality
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Interventions
Participants will undergo a noninvasive electroencephalogram (EEG) recording to measure brain activity in response to auditory stimuli. During the procedure, participants will listen to simple sounds through headphones while brain signals are recorded. No behavioral responses are required.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07569445