RecruitingPhase 1NCT07571200

A Master Protocol (OLMP): A Study of LY4256984 in Participants With Amyotrophic Lateral Sclerosis (ALS)

A Master Protocol for Open-Label Extension Studies to Evaluate the Long-Term Safety and Tolerability of Interventions in Various Stages of Clinical Development in Participants With Amyotrophic Lateral Sclerosis


Sponsor

Eli Lilly and Company

Enrollment

32 participants

Start Date

May 14, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

Study OLMP is a master protocol that will support a collection of individual sub studies that share key design components. Participants from the originator study OWAA (NCT07100119) will be assigned to the appropriate study treatment group: Sporadic Amyotrophic Lateral Sclerosis OL01 (NCT07571174). The studies aim to evaluate the safety and tolerability of different treatments in participants with Amyotrophic Lateral Sclerosis (ALS) that will last at least 96 weeks.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called LY4256984 for people with amyotrophic lateral sclerosis. The study is currently recruiting participants at 9 locations. People eligible for this study include aged 18 Years to 80 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGLY4256984

Administered IT


Locations(9)

UZ Leuven

Leuven, Belgium

McGill University Health Centre

Montreal, Canada

Sunnybrook Research Institute

Toronto, Canada

Universitätsklinikum Schleswig-Holstein

Lübeck, Germany

Universitätsmedizin Rostock

Rostock, Germany

Universitaetsklinikum Ulm

Ulm, Germany

Universitair Medisch Centrum Utrecht

Utrecht, Netherlands

Hospital Universitari de Bellvitge

L'Hospitalet de Llobregat, Spain

Hospital Universitari i Politecnic La Fe

Valencia, Spain

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NCT07571200


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