RecruitingPhase 3NCT07584525
Dexamethasone in Tick-borne Encephalitis
Treatment With Dexamethasone in Patients With Tick-borne Encephalitis: Randomized Clinical Trial
Sponsor
University Medical Centre Ljubljana
Enrollment
200 participants
Start Date
May 3, 2024
Study Type
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to investigate the efficacy of dexamethasone in patients with tick-borne encephalitis.
Eligibility
Min Age: 18 Years
Inclusion Criteria4
- age 18 years or older and
- clinical signs and symptoms of meningoencephalitis or meningomyelitis and
- cerebrospinal pleocytosis and
- serological confirfmation of tick-borne encephalitis virus infection
Exclusion Criteria9
- pregnancy or
- severe neurological impairment befor tick-borne encephalitis or
- systemic corticosteroid treatment in the past 30 days or
- allergy to corticosteroids or
- immunosuppresive condition or therapy such as HIV with CD4 < 200/ml, organ or bone marrow transplant, receiving chemotherapy, radiotherapy or any other immunosuppresive therapy, primary immunodeficiency, hematological maliganncy or
- ventricular shunt or
- endoscopically documented peptic gastric ulcer in the past six months or gastrointestinal bleeding with hemoglobin drop ≥ 20 units or
- uncontrolled diabetes with hyperglicemia or
- antiviral therapy with rilpivirin
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Interventions
DRUGDexametasone
dexamethasone 4 mg tid
DRUGSaline (0.9% NaCl)
20 ml saline
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07584525