Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease
Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease: the LAST-COP Study
Maria Cecilia Hospital
60 participants
Mar 18, 2024
INTERVENTIONAL
Conditions
Summary
Numerous clinical studies have highlighted the role of macrophages in the destabilization of coronary lesions; however, there is limited literature on the relationship between circulating monocytes and intraplaque macrophages. This study aims to evaluate and compare the presence of macrophages and their subsequent activation within coronary and peripheral atherosclerotic lesions, and to correlate these findings with the distribution of circulating monocyte subpopulations.
Eligibility
Inclusion Criteria4
- Patients with chronic coronary artery disease;
- Patients with no-ST elevation acute coronary syndrome;
- Patients with chronic claudication (Rutherford II-III)
- Patients with critical limb ischemia (Rutherford IV-V).
Exclusion Criteria8
- Severe renal dysfunction
- Severe valve disease
- Advanced heart failure
- Advanced liver disease
- Chronic inflammatory or autoimmune disease
- Use of antinflammatory drugs
- Acute infection
- Recent surgical procedures
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Interventions
assessment of the number of infiltrating macrophages
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07588295