RecruitingPhase 1Phase 2NCT07594106

REGN15505 (PSMAx4-1BB) Alone or in Combination With Cemiplimab or REGN4336 (PSMAxCD3) in Adult Patients With Metastatic Castration-Resistant Prostate Cancer and Clear Cell Renal Cell Carcinoma

Phase 1/2 Study of REGN15505 (a PSMAx4-1BB Bispecific Antibody) Administered Alone or in Combination With Cemiplimab or REGN4336 (a PSMAxCD3 Bispecific Antibody) in Patients With Metastatic Castration-Resistant Prostate Cancer and Clear Cell Renal Cell Carcinoma


Sponsor

Regeneron Pharmaceuticals

Enrollment

265 participants

Start Date

Jul 20, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This study is researching a new drug called REGN15505 when used alone or in combination with cemiplimab or in combination with REGN4336 in adult patients with mCRPC and ccRCC. The goal is to explore new ways to treat these cancers by helping immune cells target and destroy cancer cells. The study will evaluate the use of REGN15505 when administered alone, in combination with cemiplimab, or in combination with REGN4336 for: * Any side effects of study drugs * How well the study drugs work * How much REGN15505, cemiplimab, and REGN4336 are in the blood at different times * If the body makes antibodies to REGN15505 or REGN4336, which may mean the study drugs will not work as well as expected * What is the best dose of REGN15505 when administered alone and with cemiplimab and the best dose of REGN15505 and REGN4336 when used in combination


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called REGN15505, a drug called REGN15505+Cemiplimab, and others for people with clear-cell renal-cell carcinoma (ccrcc) and metastatic castration-resistant prostate cancer (mcrpc). The study is currently recruiting participants at 4 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGREGN15505

Administered per protocol

DRUGREGN15505+Cemiplimab

Administered per protocol

DRUGREGN15505+REGN4336

Administered per protocol


Locations(5)

City of Hope Phoenix

Goodyear, Arizona, United States

City of Hope

Duarte, California, United States

H. Lee Moffitt Cancer Center

Tampa, Florida, United States

City of Hope Chicago, City of Hope Cancer Center Chicago

Zion, Illinois, United States

The University of Texas MD Anderson Cancer Center

Houston, Texas, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT07594106


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