Effects of Different Tunnel Methods in PICC Catheterization
Effects of Different Tunnel Methods in PICC Catheterization: A Randomized Controlled Trial
Sun Yat-sen University
284 participants
Apr 1, 2026
INTERVENTIONAL
Conditions
Summary
This prospective randomized controlled trial compares the effectiveness and safety of one-needle and two-needle tunneling techniques for peripherally inserted central catheter (PICC) placement, aiming to identify the optimal tunneling method to reduce catheter-related complications.
Eligibility
Inclusion Criteria5
- Aged between 18 and 75 years old;
- Educational level of primary school or above, with basic listening, speaking, reading and writing abilities, and capable of completing the questionnaire independently;
- Receiving tunneled PICC catheterization for the first time, with 4Fr single-lumen solo PICC catheter indwelling;
- Able to attend regular PICC maintenance at our hospital as scheduled after catheterization;
- Voluntarily participate in this study and sign the informed consent form for this study as well as the informed consent form for PICC catheterization.
Exclusion Criteria5
- Patients with coagulation dysfunction (INR > 1.5 / PLT < 50×10⁹/L);
- Pregnant or lactating women;
- Patients with BMI < 18.5 kg/m²;
- Patients receiving PICC catheterization via lower extremity veins;
- Patients with known or suspected allergy to components of PICC catheters.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
1. Local anesthesia is administered at the puncture site，Ultrasound guidance is used for vascular puncture and assisted subcutaneous tunnel creation，the puncture needle travels 4 cm through the subcutaneous tissue before entering the blood vessel; 2. The guide wire is inserted along the puncture needle; 3. skin dilation; 4. The vascular sheath is advanced into the blood vessel via the guide wire, and the catheter is inserted through the vascular sheath; 5. The catheter tip position is confirmed, and the catheter is secured.
Two-needle tunnel PICC procedure: 1. Local anesthesia at puncture and catheter exit sites; 2. Ultrasound-guided vascular puncture at puncture site, guide wire inserted via puncture needle; 3. Skin dilation at both puncture and exit sites; 4. 4cm saline tunnel created with 0.9% NaCl: 10mL syringe advanced along tunnel path while injecting solution; 5. Subcutaneous tunnel formed from exit site to puncture site with tunneling tool, catheter pulled through tunnel to puncture site; 6. Vascular sheath inserted over guide wire, catheter trimmed to length, advanced through sheath after guide wire removal; 7. Vascular sheath peeled off, catheter adjusted to proper position; 8. Catheter tip position confirmed; 9. Puncture site closed with suture-free tape, both sites covered with sterile dressings, catheter secured.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07594704