RecruitingNCT07604467
The Role of CD34+ Stem Cells in the Pathogenesis of Takotsubo Syndrome
Effects of CD34+ Stem Cells on Left Ventricular Dysfunction Among Patients With Takotsubo Syndrome
Sponsor
University Medical Centre Ljubljana
Enrollment
40 participants
Start Date
Sep 6, 2021
Study Type
OBSERVATIONAL
Conditions
Summary
The underlying mechanisms of microvascular dysfunction in Takotsubo cardiomyopathy remain incompletely understood. As CD34+ cells are essential to coronary microvascular homeostasis we will investigate the potential association between CD34+ cell count and changes in left ventricular function in patients with Takotsubo cardiomyopathy at baseline and 6-month follow-up.
Eligibility
Min Age: 18 Years
Inclusion Criteria3
- Minimum age 18 years
- Established TTS per InterTak registry criteria
- Signed consent form
Exclusion Criteria13
- Patients under the age of 18 years
- Ischemic heart disease with at least one complete total occlusion
- Other concurrent cardiomyopathies
- Active infectious myocarditis
- obstructive coronary artery disease
- Previous hospital stay due to acute coronary syndrome (myocardial infarction) in the last 6 months before TTS acute event
- Previous interventional coronary artery procedure in the last 6 months before TTS acute event
- Significant valvular heart disease
- Significant peripheral artery occlusive disease
- Active or remitted hematologic malignancy
- Patients receiving immunosuppressive therapy
- Significant comorbiditeis affecting patients survival (malignancy)
- Failure to obtain freely given, informed consent form.
Interested in this trial?
Get notified about updates and connect with the research team.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07604467
Related Trials
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
NCT06935370635 locations
NORM-HF Pivotal Study
NCT075745932 locations
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
NCT0652619568 locations
Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure
NCT0567710048 locations
The AFteR Registry - Follow-up Study to Monitor the Efficacy and Safety of the Occlutech AFR in Heart Failure Patients
NCT0440558336 locations