RecruitingNCT07605715

Transcatheter vs. Surgical Treatment of Degenerative Mitral Regurgitation

Transcatheter vs. Surgical Treatment of Degenerative Mitral Regurgitation: A Comparative Study of Clinical Outcomes, Patient Experiences, and Mechanistic Insights With Multimodality Imaging


Sponsor

Cedars-Sinai Medical Center

Enrollment

60 participants

Start Date

Feb 19, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to compare the outcomes of transcatheter edge-to-edge repair (TEER) versus surgical mitral valve repair for degenerative mitral regurgitation (DMR) over the long term. The study aims to: 1. Evaluate the effectiveness and safety of TEER versus surgery in patients with DMR over long term. 2. Investigate the predictors of left ventricular dysfunction and clinical outcomes using advanced imaging techniques, such as cardiac MRI 3. Assess patient-reported recovery and quality of life outcomes using validated tools. The study focuses on improving care strategies for patients with DMR, particularly those at higher surgical risk, by identifying optimal treatment approaches and predictors of recovery.


Eligibility

Min Age: 60 Years

Inclusion Criteria1

  • Patients older than 60 years who have DMR will be included in the study

Exclusion Criteria3

  • Patients with prior history of mitral intervention or surgery will be excluded.
  • Patient records flagged "break the glass" or "research opt out" will be excluded.
  • Persons with allergy to animal dander or animal-instigated asthma will be excluded.

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Locations(1)

Smidt Heart Institute, Cedars Sinai Medical Center

Los Angeles, California, United States

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NCT07605715


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