RecruitingNot ApplicableNCT07610876

Autologous Demineralized Dentin Graft With or Without Melatonin for Immediate Implant Osseointegration

Effect of Autologous Demineralized Dentin Graft With or Without Melatonin Gel on the Osseo Integration of Immediately Placed Implants: A Randomized Clinical Study

Sponsor

Suez Canal University

Enrollment

16 participants

Start Date

Aug 11, 2025

Study Type

INTERVENTIONAL

Conditions

Dental Implants osseointegration Immediate Implant Placement

Summary

This randomized clinical study aims to evaluate the effect of autologous demineralized dentin graft (ADDG) with or without melatonin gel on the osseointegration of immediately placed dental implants in the maxillary premolar region. Sixteen patients requiring extraction and immediate implant placement will be randomly allocated into two groups. Clinical and radiographic outcomes including implant stability, peri-implant probing depth, modified bleeding index, marginal bone loss, buccal bone thickness, and bone density will be evaluated over a 9-month follow-up period.

Eligibility

Min Age: 20 Years

Inclusion Criteria8

Age above 20 years
Non-restorable maxillary premolar teeth
Candidates for immediate implant placement
Intact socket walls
Jumping gap >2 mm
Non-smokers or light smokers
No acute infection
Adequate bone for primary stability

Exclusion Criteria5

Heavy smokers
Bruxism or clenching
Uncontrolled systemic disease
Chemotherapy/radiotherapy
Immunocompromised patients

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Interventions

PROCEDUREAutologous Demineralized Dentin Graft

Autologous demineralized dentin graft prepared from extracted non-restorable teeth will be used for filling the jumping gap around immediately placed dental implants. Tooth preparation includes removal of restorations, caries, periodontal ligament, pulp tissue, calculus, and cementum, followed by grinding and demineralization using 2% nitric acid before graft placement.

DRUGMelatonin gel

Melatonin gel will be mixed with autologous demineralized dentin graft and used for filling the jumping gap around immediately placed dental implants in the maxillary premolar region to enhance osseointegration and peri-implant bone healing.