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RecruitingNot ApplicableNCT07613606

Injectable Platelet-Rich Fibrin With Minimally Invasive Non-Surgical Technique in Treatment of Periodontal Intrabony Defects

Injectable Platelet-Rich Fibrin (i-PRF) With Minimally Invasive Non-Surgical Technique in Treatment of Periodontal Intrabony Defects: A Randomized Clinical Trial

Sponsor

October 6 University

Enrollment

40 participants

Start Date

Mar 1, 2026

Study Type

INTERVENTIONAL

Conditions

Platelet-rich FibrinMinimally Invasive Non-Surgical TechniquePeriodontal Intrabony Defects

Summary

This study aims to clinically and radiographically evaluate the adjunctive effect of injectable platelet-rich fibrin (i-PRF) used in combination with a minimally invasive non-surgical technique for the regenerative treatment of intrabony periodontal defects.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

  • Patients of both genders >18 years old, medically free of systemic diseases affecting periodontal regeneration.
  • Diagnosis of 'periodontitis' stage III (grades B or C).
  • Single-rooted and multi-rooted vital teeth in either the maxilla or the mandible.
  • Presence of comparable bilateral two- or three-walled intrabony defects \[probing pocket depth (PPD), > 5 mm with intrabony defect depth ≥ 3 mm, from the alveolar crest to the defect base, at screening radiograph\] not in a furcation-involved tooth.

Exclusion Criteria6

  • Patients with systemic illness known to affect the outcome of periodontal therapy, including diabetes, immune deficiencies, etc.
  • Pregnant and lactating women
  • Current use of any form of tobacco.
  • Non-surgical periodontal treatment in the past 6 months, or surgical periodontal treatment in the past 12 months.
  • Degree 2 or 3 mobility of the involved sites.6.
  • Presence of periapical pathology, acute infection, or subgingival restoration which could interfere with clinical measurements.

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Interventions

PROCEDUREMinimally invasive non-Surgical technique

Patients will receive minimally invasive non-Surgical technique (MINST) alone

PROCEDUREMinimally invasive non-Surgical technique + platelet-rich fibrin

Patients will receive minimally invasive non-Surgical technique (MINST)+ injectable platelet-rich fibrin (i-PRF) injection

Locations(1)

October 6 University

Cairo, Egypt

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NCT07613606

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