RecruitingPhase 3NCT07614776

A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular Degeneration

A Randomized, Double-masked, Comparative Clinical Study Evaluating the Efficacy, Safety, and Immunogenicity of ABP 938 8 mg Versus EYLEA® HD (Aflibercept) Delivered Via Intravitreal Injection in Participants With Neovascular Age-related Macular Degeneration

Sponsor

Amgen

Enrollment

304 participants

Start Date

May 27, 2026

Study Type

INTERVENTIONAL

Conditions

Neovascular Age-related Macular Degeneration nAMD

Summary

The aim of this trial is to demonstrate similarity in efficacy between ABP 938 8 mg and aflibercept (US) 8 mg by evaluating the change in best corrected visual acuity (BCVA) in participants with neovascular age-related macular degeneration (nAMD)

Eligibility

Min Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called ABP 938 8 mg and a drug called Aflibercept (US) 8 mg for people with neovascular age-related macular degeneration and namd. The study is currently recruiting participants at 29 locations. People eligible for this study include aged 50 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGABP 938 8 mg

IVT injection

DRUGAflibercept (US) 8 mg

IVT injection

Locations(36)

Retina Consultants of Orange County

Fullerton, California, United States

South Coast Retina Center - RCA

Long Beach, California, United States

Retinal Consultants Medical Group, Inc.-Sacramento, Greenback Lane, (RCA)

Modesto, California, United States

California Eye Specialists Medical Group, Inc

Pasadena, California, United States

Retinal Consultants Medical Group, Inc - Sacramento - Parkcenter Drive (RCA)

Sacramento, California, United States

California Retina Consultants

Santa Barbara, California, United States

Retina Consultants of Southern Colorado (Colorado Springs)- RCA

Colorado Springs, Colorado, United States

Retina Group of New England

Waterford, Connecticut, United States

Medeye Associates - Research

Miami, Florida, United States

Retina Consultants of Southwest Florida - Naples

Naples, Florida, United States

Advanced Research, LLC

Pensacola, Florida, United States

Retina Associates

Elmhurst, Illinois, United States

Associated Vitreoretinal and Uveitis Consultants

Carmel, Indiana, United States

Mid Atlantic Retina Specialists

Hagerstown, Maryland, United States

Retina Specialists

Towson, Maryland, United States

Retina Consultants of Minnesota

Edina, Minnesota, United States

Mississippi Retina Assoc

Madison, Mississippi, United States

The Retina Institute, Research Retina Institute (RCA)

St Louis, Missouri, United States

Vision Research Center Eye Associates of New Mexico

Albuquerque, New Mexico, United States

Ophthalmic Consultants of Long Island - Research

Oceanside, New York, United States

NC Retina Associates-RCA

Wake Forest, North Carolina, United States

Retina Consultants of South Carolina, Charleston Neuroscience institute - Blufffon (RCA)

Beaufort, South Carolina, United States

Charleston Neuroscience Institute

Charleston, South Carolina, United States

Palmetto Retina Center - Main (RCA)

Columbia, South Carolina, United States

Retina Consultants of South Carolina, Charleston Neuroscience Institute- Ladson (RCA)

Ladson, South Carolina, United States

Palmetto Retina Center, Florence (RCA)

West Columbia, South Carolina, United States

Texas Retina Associates (TRA) - Arlington

Arlington, Texas, United States

Austin Retina Associates - Ophthalmology/Retina

Austin, Texas, United States

Texas Retina Associates (TRA) - Dallas Main

Dallas, Texas, United States

Texas Retina Associates - Fort Worth

Fort Worth, Texas, United States

Retina Consultants of Texas - Katy Retina Center

Houston, Texas, United States

Retina Consultants of Texas - Schertz

Schertz, Texas, United States

Retina Associates of Utah - Retina Specialist

Salt Lake City, Utah, United States

Emerson Clinical Research- Virginia Retina Specialists

Falls Church, Virginia, United States

Vitreoretinal Associates of Washington

Bellevue, Washington, United States

Retina Center NW PLLC

Silverdale, Washington, United States

View Full Details on ClinicalTrials.gov

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NCT07614776

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