Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage
Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage (SAH): a Prospective Observational Study
Massachusetts General Hospital
40 participants
Mar 3, 2024
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to understand if angiographic cerebral vasospasm (CV) can be predicted by levels of nitric oxide (NO) consumption in patients with aneurysmal subarachnoid hemorrhage (SAH). To reach this goal, the investigators will compare NO consumption levels in SAH and non-SAH patients. NO consumption levels will be analyzed from samples of participants' cerebral spinal fluid (CSF).
Eligibility
Inclusion Criteria2
- Adult
- patient with SAH and with an external ventricular drainage (EVD) placed within 24 hours after the onset of the hemorrhage
Exclusion Criteria8
- pregnancy
- pre-existing neurological comorbidities
- coagulation disorders
- anemia
- absence of a good cranial window to perform Transcranial Doppler (TDC)
- presence of >50% stenosis of carotid arteries confirmed by doppler ultrasound
- Technical problems on EVD that prevent CSF withdrawals
- For the control group, we will invite to participate patients without neurological comorbidities undergoing spinal anesthesia in the operating room or with a spinal drain for major vascular surgery.
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Locations(2)
View Full Details on ClinicalTrials.gov
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NCT07614906