Prophylactic Antibiotics in Preventing Surgical Site Infection After Hepatobiliary Surgery in High-Resistant Settings
Prophylactic Antibiotics in Preventing Surgical Site Infection After Hepatobiliary Surgery in High-Resistant Settings: A Randomized Clinical Trial
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
378 participants
May 24, 2026
INTERVENTIONAL
Conditions
Summary
To analyse the efficacy of different preoperative prophylactic antimicrobial regimens for perioperative infection prevention in patients undergoing hepatobiliary surgery in a high antimicrobial resistance setting.
Eligibility
Inclusion Criteria4
- Adult patients aged ≥18 years;
- Deemed eligible for elective hepatobiliary surgery;
- Demonstrated comprehension of the study nature and expressed willingness to comply with trial procedures;
- Capable of providing written informed consent.
Exclusion Criteria7
- History of β-lactam allergy or hypersensitivity
- Uncontrolled preoperative infection;
- Current or recent (within the preceding month) systemic corticosteroid administration;
- Severe hepatic or renal impairment;
- Pregnancy or lactation;
- Concurrent enrolment in another clinical trial;
- Any other condition deemed by the investigator to render the patient unsuitable for study participation.
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Interventions
Participants were randomized allocated to intervention group and receive piperacillin-tazobactam as prophylactic antibiotic before hepatobiliary surgery. Participants in the cotrol group will receive cefuroxime for prophylactic antibiotic.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07620223