RecruitingPhase 2NCT07620392

An Extension Study to Assess Long-Term Safety and Efficacy of Afimkibart in Participants With Rheumatoid Arthritis

An Extension Study to Evaluate the Long-term Safety and Efficacy of Afimkibart (RO7790121) in Patients With Rheumatoid Arthritis Who Participated in Previous Afimkibart Clinical Trials

Sponsor

Hoffmann-La Roche

Enrollment

120 participants

Start Date

Jun 3, 2026

Study Type

INTERVENTIONAL

Conditions

Rheumatoid Arthritis

Summary

The study will evaluate the long-term safety and efficacy of Afimkibart (also known as RO7790121) in participants with moderate to severe Rheumatoid Arthritis (RA) who have an inadequate response or intolerance to tumor necrosis factor (TNF) and/or Janus kinase (JAK) inhibitors, and who were previously treated with Afimkibart.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Afimkibart for people with rheumatoid arthritis. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGAfimkibart

Participants will receive Afimkibart as per the schedule mentioned in the protocol.

Locations(6)

West Broward Rheumatology Associates, Inc.

Tamarac, Florida, United States

Accurate Clinical Management LLC

Houston, Texas, United States

DM Clinical Research

Tomball, Texas, United States

Centrum Kliniczno-Badawcze J. Brzezicki, B. Górnikiewicz-Brzezicka Lekarze Spó?ka Partne

Elblag, Poland

Zespol Poradni Specjalistycznych REUMED filia nr 1 Wallenroda

Lublin, Poland

Reumatop Grzegorz Rozumek Karin Pistorius Spolka Jawna

Wroclaw, Poland

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07620392

Related Trials

A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.

NCT0691680637 locations

A Phase 1, First-in-Human Study of CND319 in Healthy Participants and Patients With Rheumatic Diseases

NCT077129391 location

Creating Health Course Study for People With Rheumatological Conditions and Mood Disorders

NCT071805371 location

A Study to Evaluate the Safety, Tolerability, and Drug Levels of BMS-986454 in Participants With Rheumatoid Arthritis

NCT071719839 locations

A Study of LY4298445 in Healthy Participants and Participants With Systemic Lupus Erythematosus (SLE) or Rheumatoid Arthritis (RA)

NCT072769589 locations