RecruitingNot ApplicableNCT07631286

Ejaculatory-Sparing HoLEP vs Standard HoLEP

Ejaculatory-sparing Holmium Laser Enucleation of the Prostate (HoLEP) vs Standard HoLEP: a Randomized Controlled Trial


Sponsor

Northwestern University

Enrollment

48 participants

Start Date

Jun 1, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The objective of this study is to compare a new surgical technique for HoLEP that will allow for sparing of ejaculation post-HoLEP.


Eligibility

Sex: MALEMin Age: 18 YearsMax Age: 100 Years

Inclusion Criteria1

  • \- Patients who are sexually active with antegrade ejaculation who are undergoing HoLEP for the treatment of bothersome lower urinary tract symptoms.

Exclusion Criteria5

  • Patients with pre-existing retrograde ejaculation
  • Patients who are not sexually active
  • Patients with indwelling urinary catheter prior to surgery, neurological disease, or history of prior prostatic/urethral surgery that may impact ejaculation
  • Patients who lack decisional capacity
  • Patients unable to read/speak English

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Interventions

OTHEREjaculatory-sparing (ES-sparing) HoLEP

The ejaculatory sparing technique involves sparing the distal apex of the prostate in particular the anterior portion of the prostate which will allow for coaptation necessary for antegrade ejaculation.


Locations(1)

Northwestern University

Chicago, Illinois, United States

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NCT07631286


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