RecruitingNot ApplicableNCT07642856

Individualized Neuro-Modulation Paired With Cerebellar Therapy


Sponsor

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

Enrollment

30 participants

Start Date

Jun 30, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this project is to evaluate feasibility and preliminary efficacy of pairing personalized transcranial direct current stimulation (tDCS) with individualized rehabilitation therapy in people with cerebellar damage.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Inclusion Criteria3

  • Age 18-75 years
  • Males and Females
  • Disorders that predominantly affect the cerebellum: damage from stroke, tumor or degeneration (genetic or non-genetic causes, congenital hypoplasia).

Exclusion Criteria11

  • Diagnoses or impairments that interfere with task execution or data interpretation.
  • Heart pacemaker or other MRI-incompatible implanted metal device
  • Metallic foreign body in their eye or head
  • Experience with severe claustrophobia
  • Experience discomfort from the MRI scan, such as excessive heating of tattoos
  • Seizures or history of seizure disorder
  • Alcohol or substance use disorder (self-report)
  • Diagnosed history of severe psychiatric disorder such as depression, schizophrenia (self-report)
  • Metallic foreign body in their eye or head (except the mouth e.g. dental fillings)
  • Specific medications: tricyclic anti-depressants or neuroleptic medication
  • Any medical condition (including orthopedic, pain, cardiopulmonary or other) that limits safe participation in exercise training

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Interventions

BEHAVIORALTherapy

Each participant will choose a domain that they would like to focus on. Choices are: 1) walking and balance control, 2) hand dexterity and arm control, or 3) speech articulation, prosody, and intelligibility.


Locations(1)

Motion Analysis Lab in the Kennedy Krieger Institute

Baltimore, Maryland, United States

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NCT07642856


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