Multivitamin and Mineral Supplementation and Healthy Aging
The Impacts of Multivitamin and Mineral Supplementation on Cellular Metabolism and Healthy Aging
University of California, San Diego
150 participants
Sep 5, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this study is to determine the impact of MVM supplementation on clinical and biochemical markers associated with healthy aging, with a particular focus on mitochondrial function and metabolism. Specifically, changes in mitochondrial respiration using isolated blood cells will be measured. This method has been used to compare with various other age-related markers of health such as physical function, gait speed, and resting metabolic rate. It is hypothesize that MVM supplementation will impact the function of blood cells. We will also explore how MVM supplementation impacts other markers of health, including serum nutrient levels, metabolomic profiles, physical function, and skeletal muscle composition and quality. These comprehensive assessments will provide insights into the potential benefits of MVM supplementation for healthy aging and address critical gaps in our understanding of its immediate effects. Further, this study will aid in the understanding of how multivitamin supplements can support heathy aging in mid-life adults, a key time to start including wellness programs in our lives. The study cohort will consist of 150 sedentary men and women aged 40-60-years of age. A double-blind, three-arm, placebo-controlled randomized clinical trial will be conducted. Participants will receive a daily oral tablet containing one of two possible formulations of vitamins and minerals or a placebo. The three groups will be MVM "GOLD" blend formula, the US Restage MVM "US CORE", and the placebo group.
Eligibility
Inclusion Criteria5
- IPAQ-SF categorical score of low or moderate physical activity (indicating sedentary lifestyle).
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Between 40-60 years of age
- BMI ≥18.5 and ≤32 kg/m2
- Weight stable for the prior 6 weeks
Exclusion Criteria9
- Is pregnant or nursing.
- Current smoker.
- Diabetes (FPG > 180 mg/dL or A1c>8)
- Heart or cardiovascular condition, including coronary artery disease, congestive heart failure, diagnosed abnormality of heart rhythm, atrial fibrillation and/or a history of myocardial infarction
- Cancer or history of cancer within the past 5 years
- Sensory or physical impairment that would prevent participation
- Parkinson's disease, multiple sclerosis or other neurological condition, including a previous stroke, that may be causing impaired muscle function or mobility
- Consistent use of any multivitamin and mineral supplement use, or any supplement that may interfere with measurements or biological outcomes (including but not limited to: NAD+ supplements, MitoQ)
- Individuals with drug interactions as determined by the study physician
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Interventions
Consists of a pill containing a 22-ingredient blend of vitamins and minerals 1 pill will be taken daily, 7 days/week for 12 weeks
Pills, participants will take contain a 17-ingredient blend of vitamins and minerals. Instructions: 1 pill each day, 7 days/week for 12 weeks
Pill contains no vitamins or minerals. 1 pill will be taken daily, 7 days/week, for 12 weeks
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07642869