RecruitingNot ApplicableNCT07674264

Cross-System Effects of Acute Intermittent Hypercapnia-Based Interventions in PD

A Pilot Study of Acute Intermittent Hypercapnia-Based Interventions on Upper Airway and Axial Motor Function in Parkinson's Disease

Sponsor

University of Florida

Enrollment

32 participants

Start Date

Jun 20, 2026

Study Type

INTERVENTIONAL

Conditions

Parkinson Disease Parkinsonism

Summary

Parkinsonism impairs upper airway and axial motor control, leading to disordered breathing, reduced speech volume, and ineffective cough. Symptoms are poorly addressed by current therapies. This randomized pilot trial tests whether a single session of acute intermittent hypercapnic hypoxia (AIHH) or hypercapnic normoxia (AIHN) improves upper airway and axial motor function in Parkinsonism, and explores biomarker correlates of intervention responsiveness.

Eligibility

Min Age: 40 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Acute intermittent hypercapnic hypoxia (AIHH) and Acute intermittent hypercapnic normoxia (AIHN) for people with parkinson disease and parkinsonism. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 40 Years to 75 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERAcute intermittent hypercapnic hypoxia (AIHH)

Participants randomized to Group 1 will breathe brief bouts of AIHH, involving 15, 1.5-min exposures to 9-10% O2 and 4-5% CO2, alternated with 1 minute of 21% O2 (room air).

OTHERAcute intermittent hypercapnic normoxia (AIHN)

Participants randomized to Group 2 will breathe brief bouts of AIHN, involving 15, 1.5-min exposures to 21% O2 and 4-5% CO2, alternated with 1 minute of 21% O2 (room air).