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Effects of Preoperative Sleep Disorders on Perioperative Anesthesia Depth and Recovery Quality in Patients Undergoing Noncardiac Surgery

Effects of Preoperative Sleep Disorders on Perioperative Anesthesia Depth and Recovery Quality in Patients Undergoing Noncardiac Surgery: A Single-Center, Prospective, Observational Cohort Study

Sponsor

General Hospital of Ningxia Medical University

Enrollment

80 participants

Start Date

Jun 16, 2026

Study Type

OBSERVATIONAL

Conditions

Emergence Time

Summary

A Single-Center, Prospective Observational Cohort Study Comparing Perioperative Electroencephalographic Anesthesia Depth Parameters (Electroencephalographic Index, SE/RE Entropy, Burst Suppression Ratio) Between Patients With Preoperative Sleep Disorders and Those Without; To Identify the Independent Effects of Preoperative Sleep Disorders on the Speed of Electroencephalographic Recovery During Emergence, Electroencephalographic Status at Extubation, Intra-PACU Electroencephalographic Fluctuations, and Quality of Emergence.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria6

  • \- Aged 18 to 65 years, with American Society of Anesthesiologists (ASA) physical status classification Ⅰ-Ⅲ;
  • Elective non-cardiac surgery with an expected operative duration longer than 2 hours;
  • Preoperative Mini-Mental State Examination (MMSE) score ≥ 24;
  • Completion of the Pittsburgh Sleep Quality Index (PSQI) assessment 1 day before surgery;
  • Absence of severe cardiac, hepatic, renal or cerebral diseases, and no history of psychiatric or neurological disorders;
  • Voluntary provision of written informed consent.

Exclusion Criteria11

  • Preoperative severe cognitive dysfunction, history of traumatic brain injury or stroke;
  • Long-term regular use of sedative-hypnotics, antidepressants or antipsychotics;
  • Intraoperative massive hemorrhage, cardiac arrest, or severe hypoxemia (SpO₂ < 90% lasting for more than 5 minutes);
  • Inability to cooperate with EEG monitoring or scale evaluation;
  • Pregnancy or breastfeeding status.
  • Drop-out Criteria :
  • Cancellation of scheduled surgery/anesthesia or postoperative admission to the intensive care unit (ICU);
  • Patient withdrawal of study participation;
  • Intraoperative massive hemorrhage, cardiac arrest, or severe hypoxemia (SpO₂ < 90% lasting for more than 5 minutes);
  • Development of severe postoperative complications;
  • Incomplete data collection or voluntary trial withdrawal.

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Interventions

COMBINATION_PRODUCTExposed cohort (sleep disorder group)

All participants receive standardized sevoflurane-based general anesthesia for elective non-cardiac surgery. Continuous perioperative electroencephalographic (EEG) monitoring is performed throughout induction, maintenance and emergence phase. Serial scale assessments including PSQI, PSG, MMSE, NRS and delirium evaluation, as well as serial serum BDNF testing are conducted at designated perioperative time points. This cohort consists of patients with preoperative Pittsburgh Sleep Quality Index (PSQI) score ≥ 7, defined as preoperative sleep disorders.

COMBINATION_PRODUCTControl cohort (non-sleep disorder group)

All participants receive identical standardized sevoflurane-based general anesthesia and continuous full-course EEG monitoring during elective non-cardiac surgery. Uniform perioperative scale assessments (PSQI, PSG, MMSE, NRS, postoperative delirium screening) and serial serum BDNF detection are completed at unified time nodes. This control cohort includes patients with preoperative Pittsburgh Sleep Quality Index (PSQI) score \< 7 without preoperative sleep disturbance.

Locations(1)

General hospital of Ningxia medical university

Yinchuan, Ningxia, China

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NCT07675993