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RecruitingNot ApplicableNCT07683650

Hyaluronic Acid and I-PRF Mixture for TMJ Disc Displacement Management

Evaluation of Hyaluronic Acid and I-PRF Mixture for Intra-articular Injection Following Arthrocentesis in The Management of TMJ Reducible Disc Displacement: A Four Arm Comparative Trial

Sponsor

Mansoura University

Enrollment

72 participants

Start Date

Jan 6, 2026

Study Type

INTERVENTIONAL

Conditions

TMJ Disc Displacement With Reduction

Summary

The aim of this study is to evaluate the efficacy of hyaluronic acid and I-PRF mixture for intra-articular injection following arthrocentesis in the management of TMJ reducible disc displacement.

Eligibility

Min Age: 18 YearsMax Age: 45 Years

Inclusion Criteria5

  • Age: 18 - 45 years.
  • Patients with disc displacement with reduction in any of the TMJs.
  • arthralgia.
  • Limited unassisted mouth opening.
  • Co-operative patients.

Exclusion Criteria8

  • Patients with previous history of TMJ minimally invasive interventions.
  • Patients with autoimmune or connective tissue diseases affecting the joints.
  • Patients with neurological disorders.
  • Patients with a history of condylar fractures or ankylosis.
  • Patients with psychological problems.
  • Patients receiving non-steroidal anti-inflammatory drugs within 48 hours preoperatively, or systemic use of corticosteroids within 2 weeks.
  • Patients on anticoagulants, suffering from platelet function disorders or fibrinogen deficiency.
  • Patients with moderate to severe myogenic pain.

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Interventions

PROCEDURE18 joints that receive arthrocentesis using 100 ml of ringer lactate solution

18 joints that receive arthrocentesis using 100 ml of ringer lactate solution

PROCEDUREArthrocentesis followed by hyaluronic acid injection

18 joints that receive arthrocentesis using 100 ml of ringer lactate solution followed by intra-articular injection of 1 ml of hyaluronic acid

PROCEDUREArthrocentesis followed by injection of hyaluronic acid and betamethasone mixture

18 joints that receive arthrocentesis using 100 ml of ringer lactate solution followed by intra-articular injection of hyaluronic acid and betamethasone mixture

PROCEDUREArthrocentesis followed by injection of hyaluronic acid and I-PRF mixture

18 joints that receive arthrocentesis using 100 ml of ringer lactate solution followed by intra-articular injection of hyaluronic acid and I-PRF mixture

Locations(1)

Faculty of Dentistry Mansoura University

Al Mansurah, Egypt

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NCT07683650