Influence of Early Wound Healing on the Outcomes of Regenerative Periodontal Surgery
Influence of Early Wound Healing on the 12-month Clinical and Radiographic Outcomes of Regenerative Periodontal Surgery: a Prospective Observational Cohort Study
University of Roma La Sapienza
100 participants
Jun 1, 2026
OBSERVATIONAL
Conditions
Summary
This study investigates whether early post-surgical healing (1-2 weeks) affects the 12-month clinical and radiographic success of periodontal regenerative therapy in patients with Stage III-IV periodontitis.
Eligibility
Inclusion Criteria3
- Diagnosis of Stage III or IV Periodontitis.
- Presence of at least one deep interproximal infrabony defect (Probing Pocket Depth \[PPD\] >= mm, radiographic depth >= 3 mm).
- Optimal oral hygiene: Full-Mouth Plaque Score (FMPS) and Full-Mouth Bleeding Score (FMBS) < 15% at the time of surgery.
Exclusion Criteria2
- Systemic: ASA III-VI classification; uncontrolled diabetes; medications causing gingival overgrowth (e.g., nifedipine, cyclosporine, phenytoin); heavy smokers (>10 cigarettes/day); pregnancy or lactation.
- Local: Third molars; Grade III tooth mobility; inadequate endodontic treatment; teeth undergoing orthodontic treatment; teeth supporting removable or implant-linked fixed prosthetics.
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Interventions
All subjects undergo surgical debridement of the infrabony defect followed by a regenerative approach (biologics, bone grafts, or blood clot alone) using papilla preservation techniques (MIST, M-MIST, MPPT, SPPF, or SFA).
Locations(1)
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NCT07683962