High-Intensity Peripheral Magnetic Stimulation in Traumatic Peripheral Nerve Injury
Clinical and Electrophysiological Evaluation of the Effect of High-Intensity Peripheral Magnetic Stimulation in Traumatic Peripheral Nerve Injury: A Randomized, Double-Blind, Sham-Controlled Trial
Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
40 participants
Aug 13, 2026
INTERVENTIONAL
Conditions
Summary
Traumatic peripheral nerve injury is a common cause of chronic neuropathic pain, muscle weakness, and functional limitation, particularly in young and active individuals. Current conservative and pharmacological treatments often provide incomplete relief or carry side effects. High-intensity peripheral magnetic stimulation (PMS) is a non-invasive method that may help reduce neuropathic pain and support motor recovery, but evidence in traumatic nerve injury is limited. This randomized, double-blind, sham-controlled trial aims to evaluate whether high-intensity PMS, added to a standardized therapeutic exercise program, improves pain, function, quality of life, and electrophysiological measures in adults with traumatic peripheral nerve injury. Participants will be randomly assigned to receive either active PMS or sham PMS, in addition to the same exercise program. Outcomes will be assessed at baseline, 4 weeks, and 8 weeks.
Eligibility
Inclusion Criteria8
- Age between 18 and 65 years
- Traumatic peripheral nerve injury
- Unilateral traumatic peripheral neuropathy confirmed by electromyography (EMG)
- Nerve injury occurring at least 3 months prior
- Douleur Neuropathique 4 (DN4) score ≥ 4
- Visual Analog Scale (VAS) score ≥ 4
- Manual Muscle Testing score < 5
- No analgesic use, or stable analgesic therapy for the past month (no dose changes)
Exclusion Criteria10
- Active infection or malignancy
- Metal implant or shrapnel in the application area
- Electronic implants (e.g., cardiac pacemaker, spinal cord stimulator, deep brain stimulator)
- Central nervous system diseases
- Non-traumatic causes of neuropathy (e.g., radiculopathy, diabetic neuropathy, entrapment neuropathies, HIV-related neuropathy, trigeminal neuralgia)
- Complete nerve injury
- Injury involving three or more peripheral nerves or plexus injury
- History of peripheral nerve surgery or injection within the past 3 months
- Active psychiatric illness
- Coagulopathy
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Interventions
High-intensity peripheral magnetic stimulation delivered via an inductive coil placed over the injured peripheral nerve, using a predefined neuropathy protocol (approximately 10 minutes per session, variable frequencies 1-60 Hz). Stimulation intensity is increased until motor activity is elicited and kept constant during the session. Applied 3 times per week for 3 weeks (9 sessions total).
Sham peripheral magnetic stimulation using the same device, session duration, and application site, with the applicator coil reversed to prevent effective delivery of the magnetic field to the target tissue. Device screen and audible feedback are maintained to preserve blinding. Applied 3 times per week for 3 weeks (9 sessions total).
Standardized individualized therapeutic exercise program including active range of motion exercises, strengthening exercises, stretching exercises, proprioception and balance exercises, and occupational therapy for activities of daily living. Delivered for 20 minutes per day, 5 days per week, over 3 weeks.
Locations(1)
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NCT07705490