Plasma Exchange in Pediatric Autoimmune Encephalitis
Daily Versus Alternate-Day Plasma Exchange in Pediatric Autoimmune Encephalitis: A Randomized Controlled Trial
Menoufia University
22 participants
Aug 1, 2026
INTERVENTIONAL
Conditions
Summary
The aim of the study will be to compare the efficacy of daily plasma exchange (PLEX) versus alternate-day PLEX in achieving a favorable functional outcome in children with autoimmune encephalitis. The study population will be divided into two groups, the first group will perform PLEX on consecutive days and the second one will perform it every other day. Then, A Favorable functional outcome measure defined as modified Rankin Scale (mRS) score ≤ 2. The mRS will be assessed by a blinded assessor at the end of the sessions to determine which method has superior efficacy in treatment of autoimmune encephalitis.
Eligibility
Plain Language Summary
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Interventions
Plasma exchange (PE) sessions to be done daily for Arm A
Plasma exchange (PE) sessions to be done on every other day for Arm B
Locations(1)
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NCT07707739