Airway Occlusion Pressure (P0.1) Guided Pressure Support Ventilation Versus Conventional Management in Weaning Window Patients
Airway Occlusion Pressure (P0.1) Guided Pressure Support Ventilation Versus Conventional Management in Weaning Window Patients: A Randomized Controlled Trial
Tanta University
80 participants
Feb 1, 2026
INTERVENTIONAL
Conditions
Summary
This study aims to determine whether Airway Occlusion Pressure (P0.1) Guided Pressure Support Ventilation is superior to conventional management for patients in weaning windows.
Eligibility
Inclusion Criteria4
- Mechanically ventilated adult patients ≥ 21 years.
- Patients on pressure support ventilation for at least 24 hours and clinically determined to be in the weaning window (transition between assisted ventilation and spontaneous ventilation) with improving respiratory status.
- Hemodynamically stable \[mean arterial pressure (MAP) ≥60 mmHg\].
- All patients will be required to have light sedation with a Richmond Agitation-Sedation Scale (RASS) score between -1 and 0 to allow reliable assessment of respiratory drive.
Exclusion Criteria8
- Patients with neuromuscular disorders affecting respiratory drive
- Glasgow Coma Scale (GCS) score below 8
- Cervical spinal cord injury
- Receipt of neuromuscular blockers within the previous 24 hours
- Morbid obesity resulting in unreliable respiratory mechanics
- Pregnancy
- Deep sedation defined as RASS ≤ -2
- Hemodynamic instability requiring escalating vasopressor support.
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Interventions
Patients will receive a conventional pressure support ventilation protocol.
Patients will receive airway occlusion pressure (P0.1)-guided pressure support ventilation (PSV).
Locations(1)
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NCT07709182