RecruitingPhase 3NCT07724132

An Evaluation of Treatments for Sustained Clinical Response (18 Months) in Symptomatic Alzheimer's Disease

Alzheimer's Disease- Systematic Multi-Arm Adaptive Randomised Trial


Sponsor

University College, London

Enrollment

1,200 participants

Start Date

Jul 24, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

A multicentre, interventional, multi-arm, multi-stage Phase 3 trial including randomisation, double blinding, placebo control evaluation of treatments for sustained clinical response (18 months) in symptomatic Alzheimer's Disease in a population representative of people with Alzheimer's disease in the UK.


Eligibility

Min Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Atomoxetine, a drug called Metformin 1000 mg Oral Tablet, and others for people with alzheimer disease dementia, alzheimer's disease (ad), and other related conditions. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 55 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPlacebo

Oral capsule matching active treatments

DRUGAtomoxetine

Atomoxetine (Oral, up to 100 mg/day)

DRUGMetformin 1000 mg Oral Tablet

Metformin IR Oral, up to 2000 mg/day


Locations(2)

Windsor Research Unit

Cambridge, United Kingdom

Two Bridges Research & Development Clinic

Chertsey, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT07724132


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