RecruitingPhase 2NCT07733180

A Study Investigating Alternate Schedules of Tislelizumab Plus Chemotherapy in Japanese Patients With First-line Advanced ESCC

A Phase 2 Study of Tislelizumab Administered With Alternative Dosing Schedules Plus Chemotherapy as First-line Treatment in Japanese Patients With Unresectable Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma


Sponsor

BeOne Medicines

Enrollment

30 participants

Start Date

Sep 14, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to evaluate the pharmacokinetic (PK) profile, safety, and efficacy of tislelizumab administered once every 2 weeks (Q2W) or once every 4 weeks (Q4W) in combination with chemotherapy as first-line treatment in Japanese participants with previously untreated, unresectable locally advanced, or metastatic esophageal squamous cell carcinoma (ESCC).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called 5-fluorouracil (5-FU), a drug called Leucovorin, and others for people with advanced esophageal squamous cell carcinoma and metastatic esophageal squamous cell carcinoma. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGTislelizumab

Administered by intravenous infusion

DRUGOxaliplatin

Administered by intravenous infusion

DRUGLeucovorin

Administered by intravenous infusion

DRUG5-fluorouracil (5-FU)

Administered by intravenous infusion


Locations(1)

Osaka Keisatsu Hospital

Osaka, Japan

View Full Details on ClinicalTrials.gov

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NCT07733180


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