RecruitingNot ApplicableNCT07736963

Discontinuation Recommendations for GLP-1 Receptor Agonists Prior to Colonoscopy: A Randomized Controlled Trial in Taiwan.

Sponsor

Fu Jen Catholic University Hospital

Enrollment

240 participants

Start Date

Jun 1, 2026

Study Type

INTERVENTIONAL

Conditions

GLP - 1

Summary

This study aims to evaluate the impact of different discontinuation intervals of GLP-1 receptor agonists prior to colonoscopy on bowel preparation quality and the need for repeat colonoscopy, in order to establish appropriate discontinuation recommendations.

Eligibility

Min Age: 18 YearsMax Age: 90 Years

Inclusion Criteria6

Individuals who are scheduled to undergo total colonoscopy for any reasons
Age between 18 to 70 years.
ECOG Performance status is 0 or 1.
Written consent to participate in the study has been obtained.
Outpatient department patient
Stop at least 3 days if current using medications that promote or inhibit gastrointestinal motility.

Exclusion Criteria11

Presence of severe comorbid conditions that preclude the safe performance of colonoscopy (e.g., unstable angina, recent myocardial infarction, decompensated heart failure, chronic respiratory disease, or bleeding diathesis).
History of prior gastric, small bowel, or colorectal segmental resection (patients with isolated appendectomy are eligible).
Family history of hereditary colorectal cancer syndromes.
Current or prior diagnosis of inflammatory bowel disease.
Known colorectal polyposis syndromes.
Any other condition deemed inappropriate for study participation at the discretion of the treating physician.
Body mass index (BMI) > 40 kg/m².
Diagnosis of liver cirrhosis.
Diagnosis of Parkinson's disease.
Diagnosis of dementia.
Use of tricyclic antidepressants or opioid medications for more than 3 months.